Why only some patients get liver disease: New protein pathway may help forecast alpha1-antitrypsin outcomes
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Alpha1-antitrypsin deficiency, an inherited disorder affecting 100,000 people in the U.S., causes a progressive and incurable lung disease. A subset of patients with the condition—about 10% to 15%—also develop liver disease because of the accumulation of the aggregated protein variant resulting from the genetic error that causes the disease. Now, researchers at Washington University School […]